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Type  disruption phenotype Description  Mice grow and develop normally but exhibit splenomegaly, selective augmentation of IgG3 antibody response to a T-independent type II antigen, and enhanced proliferative responses of B-cells and myeloid cells by anti-IgM and granulocyte colony-stimulating factor stimulation (PubMed:9796923). Mice are prone to development of autoimmune diseases (PubMed:10485649, PubMed:11209085). In a C57BL/6J background, mice spontaneously develop lupus-like autoimmune phenotypes, characterized by proliferative arthritis and glomerulonephritis with predominant IgG3 deposition (PubMed:10485649). In a BALB/c background, mice develop autoimmune dilated cardiomyopathy with severely impaired contraction, and two-third of mice die by congestive heart failure before 30 weeks of age (PubMed:11209085). Mice lacking both Lag3 and Pdcd1/PD-1 die of severe myocarditis before 10 weeks of age in BALB/c mice (PubMed:21300912).