| First Author | Schaefer L | Year | 1999 |
| Journal | Genomics | Volume | 56 |
| Issue | 3 | Pages | 310-6 |
| PubMed ID | 10087198 | Mgi Jnum | J:51125 |
| Mgi Id | MGI:1314675 | Doi | 10.1006/geno.1998.5728 |
| Citation | Schaefer L, et al. (1999) Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien. Genomics 56(3):310-6 |
| abstractText | The Drosophila alien gene is highly homologous to the human thyroid receptor interacting protein, TRIP15/COPS2, which is a component of the recently identified signalosome protein complex. We identified the mouse homologue of Drosophila alien through homology searches of the EST database. We found that the mouse cDNA encodes a predicted 443-amino-acid protein, which migrates at similar to 50 kDa. The gene for the mouse alien homologue, named Cops2, includes 12 coding exons spanning similar to 30 kb of genomic DNA on the central portion of mouse chromosome 2. Mouse Cops2 is widely expressed in embryonic, fetal, and adult tissues beginning as early as E7.5. Mouse Cops2 cDNA hybridizes to two mRNA bands in all tissues at similar to 2.3 and similar to 4 kb, with an additional similar to 1.9-kb band in liver. Immunostaining of native and epitope tagged proteins localized the mouse Cops2 protein in both the cytoplasm and the nucleus, with larger amounts in the nucleus in some cells. (C) 1999 Academic Press. |
