| First Author | Goto A | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 1 | Pages | 97-104 |
| PubMed ID | 18066067 | Mgi Jnum | J:130487 |
| Mgi Id | MGI:3771766 | Doi | 10.1038/ni1543 |
| Citation | Goto A, et al. (2008) Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol 9(1):97-104 |
| abstractText | During a genome-wide screen with RNA-mediated interference, we isolated CG8580 as a gene involved in the innate immune response of Drosophila melanogaster. CG8580, which we called Akirin, encoded a protein that acted in parallel with the NF-kappaB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria. Akirin is highly conserved, and the human genome contains two homologs, one of which was able to rescue the loss-of-function phenotype in drosophila cells. Akirins were strictly localized to the nucleus. Knockout of both Akirin homologs in mice showed that one had an essential function downstream of the Toll-like receptor, tumor necrosis factor and interleukin (IL)-1beta signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses. |
