| First Author | Xu Y | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 12 | Pages | 1457-9 |
| PubMed ID | 21037584 | Mgi Jnum | J:166904 |
| Mgi Id | MGI:4850185 | Doi | 10.1038/nn.2664 |
| Citation | Xu Y, et al. (2010) 5-HT(2C)Rs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci 13(12):1457-9 |
| abstractText | Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished the anti-diabetic effects of meta-chlorophenylpiperazine (a 5-HT(2C)R agonist); these effects were restored when 5-HT(2C)Rs were re-expressed in POMC neurons. Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver. |
