| First Author | Mimura J | Year | 1999 |
| Journal | Genes Dev | Volume | 13 |
| Issue | 1 | Pages | 20-5 |
| PubMed ID | 9887096 | Mgi Jnum | J:52189 |
| Mgi Id | MGI:1328620 | Doi | 10.1101/gad.13.1.20 |
| Citation | Mimura J, et al. (1999) Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev 13(1):20-5 |
| abstractText | Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants. |
