| First Author | Kang-Decker N | Year | 2001 |
| Journal | Science | Volume | 294 |
| Issue | 5546 | Pages | 1531-3 |
| PubMed ID | 11711676 | Mgi Jnum | J:72756 |
| Mgi Id | MGI:2153561 | Doi | 10.1126/science.1063665 |
| Citation | Kang-Decker N, et al. (2001) Lack of acrosome formation in hrb-deficient mice. Science 294(5546):1531-3 |
| abstractText | The sperm acrosome is essential for sperm-egg fusion and is often defective in men with nonobstructive infertility. Here we report that male mice with a null mutation in Hrb are infertile and display round-headed spermatozoa that lack an acrosome. In wild-type spermatids, Hrb is associated with the cytosolic surface of proacrosomic transport vesicles that fuse to create a single large acrosomic vesicle at step 3 of spermiogenesis. Although proacrosomic vesicles form in spermatids that lack Hrb, the vesicles are unable to fuse, blocking acrosome development at step 2. We conclude that Hrb is required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis. |
