| First Author | Ishimoto T | Year | 2017 |
| Journal | Glia | Volume | 65 |
| Issue | 5 | Pages | 727-739 |
| PubMed ID | 28230289 | Mgi Jnum | J:242041 |
| Mgi Id | MGI:5904231 | Doi | 10.1002/glia.23129 |
| Citation | Ishimoto T, et al. (2017) Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain. Glia 65(5):727-739 |
| abstractText | The abnormal expression and function of myelin-related proteins contribute to nervous system dysfunction associated with neuropsychiatric disorders; however, the underlying mechanism of this remains unclear. We found here that breast carcinoma amplified sequence 1 (BCAS1), a basic protein abundant in the brain, was expressed specifically in oligodendrocytes and Schwann cells, and that its expression level was decreased by demyelination. This suggests that BCAS1 is a novel myelin-associated protein. BCAS1 knockout mice displayed schizophrenia-like behavioral abnormalities and a tendency toward reduced anxiety-like behaviors. Moreover, we found that the loss of BCAS1 specifically induced hypomyelination and the expression of inflammation-related genes in the brain. These observations provide a novel insight into the functional link between oligodendrocytes and inflammation and/or abnormal behaviors. |
