| First Author | Yang X | Year | 1997 |
| Journal | Cell | Volume | 89 |
| Issue | 7 | Pages | 1067-76 |
| PubMed ID | 9215629 | Mgi Jnum | J:41242 |
| Mgi Id | MGI:893321 | Doi | 10.1016/s0092-8674(00)80294-9 |
| Citation | Yang X, et al. (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89(7):1067-76 |
| abstractText | The Fas cell surface receptor induces apoptosis upon receptor oligomerization. We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain. Overexpression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway. A C-terminal portion of Daxx interacts with the Fas death domain, while a different region activates both JNK and apoptosis. The Fas-binding domain of Daxx is a dominant-negative inhibitor of both Fas-induced apoptosis and JNK activation, while the FADD death domain partially inhibits death but not JNK activation. The Daxx apoptotic pathway is sensitive to both Bcl-2 and dominant-negative JNK pathway components and acts cooperatively with the FADD pathway. Thus, Daxx and FADD define two distinct apoptotic pathways downstream of Fas. |
