| First Author | Gong TW | Year | 1997 |
| Journal | Biochim Biophys Acta | Volume | 1352 |
| Issue | 3 | Pages | 282-92 |
| PubMed ID | 9224952 | Mgi Jnum | J:41876 |
| Mgi Id | MGI:894583 | Doi | 10.1016/s0167-4781(97)00027-4 |
| Citation | Gong TW, et al. (1997) Complete cDNAs for CDC42 from chicken cochlea and mouse liver. Biochim Biophys Acta 1352(3):282-92 |
| abstractText | CDC42 is a member of the ras superfamily of small GTP-binding proteins that are related through the highly conserved GTP-binding domain and are involved in signal transduction pathways. Two full-length CDC42 cDNAs have been isolated: a 2148-bp chick cochlea cDNA and a 2063-bp mouse liver cDNA. Each encodes a CDC42 protein of 191 amino acids. The avian CDC42 protein differs from the mouse at only one amino acid residue, a Thr for a Ser at position 185. Both CDC42 proteins are more similar to the ubiquitous human isoform originally isolated from placenta than to the isoform isolated from fetal brain. Using a probe from the 3' UTR of the mouse liver CDC42 cDNA, we demonstrated that the mouse gene is expressed in all tissues examined. Southern blot analysis of a mouse inter-specific backcross with this gene-specific probe identified at least three CDC42-like (Cdc42l) genes in the mouse genome. Cdc42l1 was mapped to distal mouse Chromosome 4, near Cappb1. Cdc42l2 mapped more proximal on Chromosome 4, whereas Cdc42l3 mapped to the X Chromosome. |
