| First Author | Denizot F | Year | 1992 |
| Journal | Genomics | Volume | 14 |
| Issue | 4 | Pages | 857-62 |
| PubMed ID | 1478666 | Mgi Jnum | J:4516 |
| Mgi Id | MGI:53004 | Doi | 10.1016/s0888-7543(05)80105-3 |
| Citation | Denizot F, et al. (1992) YAC-assisted cloning of a putative G-protein mapping to the MHC class I region [published erratum appears in Genomics 1993 Sep;17(3):800]. Genomics 14(4):857-62 |
| abstractText | We report the successful use of whole yeast artificial chromosomes (YACs) as probes for direct positional cloning of novel expressed sequences in a given genomic fragment. The class I region of the human major histocompatibility complex, in particular the chromosomal fragment spanning the HLA-E locus, was investigated. The screening of a cDNA library with a 210-kb-long YAC clone led to the identification of a new gene, positionally conserved in the major histocompatibility complex of the mouse genome and encoding a putative GTP binding protein. Although its precise function remains unknown, the interspecies conservation of both sequence and map position suggests a regulatory or functional link with the histocompatibility cluster. |
