| First Author | Miyamoto M | Year | 1988 |
| Journal | Cell | Volume | 54 |
| Issue | 6 | Pages | 903-13 |
| PubMed ID | 3409321 | Mgi Jnum | J:17555 |
| Mgi Id | MGI:65591 | Doi | 10.1016/s0092-8674(88)91307-4 |
| Citation | Miyamoto M, et al. (1988) Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 54(6):903-13 |
| abstractText | Expression of the interferon-beta (IFN-beta) gene is induced by a variety of agents, including viruses. Evidence has been provided that a mouse nuclear factor, termed interferon regulatory factor-1 (IRF-1), specifically binds to the upstream regulatory region of the human IFN-beta gene and mediates virus-induced transcription of the gene. In this study, we describe the molecular cloning and characterization of the mouse and human cDNAs encoding IRF-1. Our results suggest that IRF-1 is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes. Surprisingly, IRF-1 gene expression is dramatically induced by Newcastle disease virus in mouse L929 cells and by Concanavalin A in spleen cells. We show here that the IRF-1 gene possesses virus-inducible promoter. |
