| First Author | Valnegri P | Year | 2011 |
| Journal | Nat Neurosci | Volume | 14 |
| Issue | 10 | Pages | 1293-301 |
| PubMed ID | 21874017 | Mgi Jnum | J:179782 |
| Mgi Id | MGI:5303043 | Doi | 10.1038/nn.2911 |
| Citation | Valnegri P, et al. (2011) A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha. Nat Neurosci 14(10):1293-301 |
| abstractText | Oligophrenin-1 regulates dendritic spine morphology in the brain. Mutations in the oligophrenin-1 gene (OPHN1) cause intellectual disability. We discovered a previously unknown partner of oligophrenin-1, Rev-erbalpha, a nuclear receptor that represses the transcription of circadian oscillators. We found that oligophrenin-1 interacts with Rev-erbalpha in the mouse brain, causing it to locate to dendrites, reducing its repressor activity and protecting it from degradation. Our results indicate the presence of a circadian oscillator in the hippocampus, involving the clock gene Bmal1 (also known as Arntl), that is modulated by Rev-erbalpha and requires oligophrenin-1 for normal oscillation. We also found that synaptic activity induced Rev-erbalpha localization to dendrites and spines, a process that is mediated by AMPA receptor activation and requires oligophrenin-1. Our data reveal new interactions between synaptic activity and circadian oscillators, and delineate a new means of communication between nucleus and synapse that may provide insight into normal plasticity and the etiology of intellectual disability. |
