| First Author | Renauld JC | Year | 1992 |
| Journal | Proc Natl Acad Sci U S A | Volume | 89 |
| Issue | 12 | Pages | 5690-4 |
| PubMed ID | 1376929 | Mgi Jnum | J:1236 |
| Mgi Id | MGI:49766 | Doi | 10.1073/pnas.89.12.5690 |
| Citation | Renauld JC, et al. (1992) Expression cloning of the murine and human interleukin 9 receptor cDNAs. Proc Natl Acad Sci U S A 89(12):5690-4 |
| abstractText | Interleukin 9 (IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression cloning in COS cells and screening with 125I-labeled IL-9. Transient expression of this cDNA produced high-affinity binding sites for IL-9. The predicted 52-kDa protein contains a putative signal peptide and a typical transmembrane domain. A cDNA for the human homologue was isolated by cross-hybridization. Transfection of this cDNA in a murine T-cell clone conferred responsiveness to human IL-9. Sequence analysis revealed that the IL-9 receptor belongs to the recently described hematopoietin receptor super-family and is expressed in membrane-bound and soluble forms. |
