| First Author | Wagener R | Year | 1997 |
| Journal | FEBS Lett | Volume | 413 |
| Issue | 1 | Pages | 129-34 |
| PubMed ID | 9287130 | Mgi Jnum | J:51112 |
| Mgi Id | MGI:1314601 | Doi | 10.1016/s0014-5793(97)00895-8 |
| Citation | Wagener R, et al. (1997) Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett 413(1):129-34 |
| abstractText | A mouse cDNA encoding for matrilin-3, the third member of the novel matrilin family of extracellular matrix proteins, was cloned. The protein precursor of 481 amino acids consists of a putative signal peptide, a short positively charged sequence, a single vWFA-like domain followed by four epidermal growth factor-like modules and a potential coiled-coil alpha-helical oligomerization domain at the C-terminus. It is the smallest member of the matrilin family with a predicted Mr of the mature protein of 48 902. The primary structure of a C-terminal portion of 310 amino acids of the human matrilin-3 was determined and showed a sequence identity to the mouse matrilin-3 of 84.8%. Northern blot hybridization of mouse matrilin-3 mRNA showed a 2.9 kb mRNA expressed in sternum, femur and trachea and indicates a cartilage-specific expression. |
