| First Author | Kim JI | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 6 | Pages | 745-51 |
| PubMed ID | 10403649 | Mgi Jnum | J:78382 |
| Mgi Id | MGI:2384335 | Doi | 10.1016/s1074-7613(00)80073-4 |
| Citation | Kim JI, et al. (1999) The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 10(6):745-51 |
| abstractText | IL-4 promotes the differentiation of naive CD4+ T cells into IL-4-producing T helper 2 (Th2) cells. Previous work provided suggestive but not conclusive evidence that the transcription factor c-Maf directed the tissue-specific expression of IL-4. It was not known whether c-Maf controlled the transcription of other Th2 cytokine genes. To elucidate the role of c-Maf in vivo, we examined cytokine production in mice lacking c-Maf (c-maf(-/-)). CD4+ T cells and NK T cells from c-maf(-/-) mice were markedly deficient in IL-4 production. However, the mice produced normal levels of IL-13 and IgE, and, when differentiated in the presence of exogenous IL-4, c-maf(-/-) T cells produced approximately normal levels of other Th2 cytokines. We conclude that c-Maf has a critical and selective function in IL-4 gene transcription in vivo. |
