| First Author | Stanton LW | Year | 1984 |
| Journal | Nature | Volume | 310 |
| Issue | 5976 | Pages | 423-5 |
| PubMed ID | 6462227 | Mgi Jnum | J:7520 |
| Mgi Id | MGI:55990 | Doi | 10.1038/310423a0 |
| Citation | Stanton LW, et al. (1984) Nucleotide sequence comparison of normal and translocated murine c-myc genes. Nature 310(5976):423-5 |
| abstractText | Plasmacytoid tumours in mice and Burkitt's lymphomas in humans display characteristic chromosomal translocations involving the c-myc proto-oncogene. Models to explain quantitative changes in c-myc expression have been proposed based on the loss of normal promoters as a result of translocation. However, alternative explanations, such as somatic mutation are needed to explain altered c-myc expression in the absence of gene breakage. We present here the nucleotide sequence of the normal murine c-myc gene. Comparison of this sequence with that of a translocated c-myc gene from a murine plasmacytoma reveals complete identity of coding sequence. One nucleotide difference was found in the non-coding first exon. This shows that qualitative changes of the c-myc gene product are not required for oncogenesis in murine plasmacytomas. In contrast, mutations are found in coding and non-coding regions of translocated c-myc genes from Burkitt's lymphomas, suggesting that the mechanisms by which c-myc is activated in plasmacytomas and Burkitt's lymphomas are different. |
