| First Author | Rosati O | Year | 2002 |
| Journal | Biochem Biophys Res Commun | Volume | 297 |
| Issue | 1 | Pages | 52-8 |
| PubMed ID | 12220507 | Mgi Jnum | J:79614 |
| Mgi Id | MGI:2388552 | Doi | 10.1016/s0006-291x(02)02130-7 |
| Citation | Rosati O, et al. (2002) Identification and characterization of murine IRAK-2. Biochem Biophys Res Commun 297(1):52-8 |
| abstractText | Interleukin-1 receptor-associated kinases (IRAKs) are pivotal signaling elements of the Toll/IL-1 receptor (TIL) family, which play a role in innate immune responses by coordinating host defence mechanisms. Presently four different forms of human IRAK molecules are cloned (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, and hu-IRAK-4). In the murine system, only three genes have been identified so far, mouse Pelle-Like Kinase (mPLK), which corresponds to human IRAK-1, mu-IRAK-M, and mu-IRAK-4. Here we report the molecular cloning and characterization of murine IRAK-2 (mu-IRAK-2), a mouse homolog to human IRAK-2 (hu-IRAK-2). Murine and human IRAK-2 molecules show 67% sequence identity, they are ubiquitiously expressed, and both practically lack autophoshorylation kinase activity. The murine molecule reveals two remarkable differences to its human counterpart: it shows a C-terminal extension and it has no stimulatory effect on IL-1 induced NF-kappa B activation when compared to hu-IRAK-2, suggesting subtle functional differences in signaling by IRAK-2 in human and mouse cells. |
