| First Author | Guo W | Year | 1996 |
| Journal | Gene | Volume | 178 |
| Issue | 1-2 | Pages | 31-4 |
| PubMed ID | 8921887 | Mgi Jnum | J:34209 |
| Mgi Id | MGI:81650 | Doi | 10.1016/0378-1119(96)00320-4 |
| Citation | Guo W, et al. (1996) Ahch, the mouse homologue of DAX1: cloning, characterization and synteny with GyK, the glycerol kinase locus. Gene 178(1-2):31-4 |
| abstractText | We cloned the murine full-length cDNA encoding Ahch, the mouse homologue of DAX1 (DSS-AHC Region on Human X Chromosome, Gene1) which is the gene responsible for human X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH). Sequence analysis revealed that the murine and human cDNAs have 65% aa identity and 75% aa similarity overall. The cysteine residues in the putative DNA binding domain, which may interact with Zn2+ ions to form zinc fingers, are 100% conserved between the two species, indicating that the novel zinc-finger structures in DAX1 may be functional. In addition, mouse interspecific backcrosses show that the Ahch gene is closely linked to the glycerol kinase locus, GyK, on the mouse X chromosome, indicating that the order of the loci is conserved in this syntenic region between mouse and human. |
