| First Author | Lobo MK | Year | 2007 |
| Journal | Nat Neurosci | Volume | 10 |
| Issue | 11 | Pages | 1395-7 |
| PubMed ID | 17934457 | Mgi Jnum | J:126659 |
| Mgi Id | MGI:3761846 | Doi | 10.1038/nn1987 |
| Citation | Lobo MK, et al. (2007) Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. Nat Neurosci 10(11):1395-1397 |
| abstractText | Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental conditioning in vivo. Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal. |
