| First Author | Ehrmann IE | Year | 1998 |
| Journal | Hum Mol Genet | Volume | 7 |
| Issue | 11 | Pages | 1725-37 |
| PubMed ID | 9736774 | Mgi Jnum | J:50115 |
| Mgi Id | MGI:1289924 | Doi | 10.1093/hmg/7.11.1725 |
| Citation | Ehrmann IE, et al. (1998) Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet 7(11):1725-37 |
| abstractText | The Delta Sxr(b) interval of the mouse Y chromosome is critical for spermatogenesis and expression of the male- specific minor transplantation antigen H-Y. Several genes have been mapped to this interval and each has a homologue on the X chromosome. Four, Zfy1, Zfy2 Ube1y and Dffry, are expressed specifically in the testis and their X homologues are not transcribed from tf ie inactive X chromosome. A further two, Smcy and Uty, are ubiquitously expressed and their X homologues escape X-inactivation. Here we report the identification of another gene from this region of the mouse Y chromosome. It encodes the highly conserved eukaryotic translation initiation factor elF-2 gamma. In the mouse this gene is ubiquitously expressed, has an X chromosome homologue which maps close to Dmd and escapes X-inactivation. The coding regions of the X and Y genes show 86% nucleotide identity and encode putative products with 98% amino acid identity. In humans, the elF-2 gamma structural gene is located on the X chromosome at Xp21 and this also escapes X-inactivation. However, there is no evidence of a Y copy of this gene in humans. We have identified autosomal retroposons of elF-2 gamma in both humans and mice and an additional retroposon on the X chromosome in some mouse strains. Ark blot analysis of eutherian and metatherian genomic DNA indicates that X-Y homologues are present in all species tested except simian primates and kangaroo and that retroposons are common to a wide range of mammals. These results shed light on the evolution of X-Y homologous genes. |
