| First Author | Gray PW | Year | 1986 |
| Journal | J Immunol | Volume | 137 |
| Issue | 11 | Pages | 3644-8 |
| PubMed ID | 3491144 | Mgi Jnum | J:20076 |
| Mgi Id | MGI:68189 | Doi | 10.4049/jimmunol.137.11.3644 |
| Citation | Gray PW, et al. (1986) Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. J Immunol 137(11):3644-8 |
| abstractText | A human interleukin 1 beta (IL 1 beta) cDNA probe was utilized to identify a homologous murine cDNA clone. The murine cDNA encodes a 269-residue protein which is 67% homologous to human IL 1 beta. The murine sequence was engineered for expression in mammalian cells and directs the synthesis of biologically active IL 1. This protein, termed murine IL 1 beta, is only 22% homologous with the previously described murine IL 1 sequence. Both IL 1 alpha and IL 1 beta are encoded by single genes, but IL 1 beta mRNA is about fivefold more abundant in a stimulated macrophage cell line. |
