| First Author | Hauser CA | Year | 1985 |
| Journal | Cell | Volume | 43 |
| Issue | 1 | Pages | 19-28 |
| PubMed ID | 4075393 | Mgi Jnum | J:32355 |
| Mgi Id | MGI:79854 | Doi | 10.1016/0092-8674(85)90008-x |
| Citation | Hauser CA, et al. (1985) Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. Cell 43(1):19-28 |
| abstractText | Human chromosome 17 contains a cluster of at least three distinct homeo box regions, Hu1, Hu2, and Hu5, within a 20 kb stretch of DNA. A mouse homeo box region, Mu1, which maps to chromosome 11, was isolated and found to contain extensive nucleotide homology with a 4 kb region encompassing the Hu1 homeo box. The conservation of these chromosomal regions between man and mouse was confirmed by nucleotide sequence analysis: approximately 380 bp of DNA are more than 90% homologous and the 61 amino acids of the homeo box domain are perfectly conserved. We found that a human teratocarcinoma cell line expresses high levels of Hu1 homeo-box-containing mRNA only after differentiation of the cells following treatment with retinoic acid. In contrast, mouse teratocarcinoma cells did not express Mu1 homeo-box-containing mRNA at any stage of differentiation, whereas the expression of such transcripts was detected in mouse embryos from 10 to 17 days of gestation. |
