| First Author | Arstikaitis P | Year | 2008 |
| Journal | Mol Biol Cell | Volume | 19 |
| Issue | 5 | Pages | 2026-38 |
| PubMed ID | 18287537 | Mgi Jnum | J:172971 |
| Mgi Id | MGI:5009384 | Doi | 10.1091/mbc.E07-08-0802 |
| Citation | Arstikaitis P, et al. (2008) Paralemmin-1, a modulator of filopodia induction is required for spine maturation. Mol Biol Cell 19(5):2026-38 |
| abstractText | Dendritic filopodia are thought to participate in neuronal contact formation and development of dendritic spines; however, molecules that regulate filopodia extension and their maturation to spines remain largely unknown. Here we identify paralemmin-1 as a regulator of filopodia induction and spine maturation. Paralemmin-1 localizes to dendritic membranes, and its ability to induce filopodia and recruit synaptic elements to contact sites requires protein acylation. Effects of paralemmin-1 on synapse maturation are modulated by alternative splicing that regulates spine formation and recruitment of AMPA-type glutamate receptors. Paralemmin-1 enrichment at the plasma membrane is subject to rapid changes in neuronal excitability, and this process controls neuronal activity-driven effects on protrusion expansion. Knockdown of paralemmin-1 in developing neurons reduces the number of filopodia and spines formed and diminishes the effects of Shank1b on the transformation of existing filopodia into spines. Our study identifies a key role for paralemmin-1 in spine maturation through modulation of filopodia induction. |
