| First Author | Gogos JA | Year | 1999 |
| Journal | Nat Genet | Volume | 21 |
| Issue | 4 | Pages | 434-9 |
| PubMed ID | 10192398 | Mgi Jnum | J:54012 |
| Mgi Id | MGI:1334001 | Doi | 10.1038/7777 |
| Citation | Gogos JA, et al. (1999) The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. Nat Genet 21(4):434-9 |
| abstractText | Hemizygous cryptic deletions of the q11 band of human chromosome 22 have been associated with a number of psychiatric and behavioural phenotypes, including schizophrenial(1-3). Here we report the isolation and characterization of PRODH, a human homologue of Drosophila melanogaster sluggish-A (sIgA), which encodes proline dehydrogenase responsible for the behavioural phenotype of the sIgA mutant(4). PRODH is localized at chromosome 22q11 in a region deleted in some psychiatric patients. We also isolated the mouse homologue of sIgA (Prodh), identified a mutation in this gene in the Pro/Re hyperprolinaemic mouse strain and found that these mice have a deficit in sensorimotor gating accompanied by regional neurochemical alterations in the brain. Sensorimotor gating is a neural filtering process that allows attention to be focused on a given stimulus, and is affected in patients with neuropsychiatric disorders(5). Furthermore, several lines of evidence suggest that proline may serve as a modulator of synaptic transmission in the mammalian brain. Our observations, in conjunction with the chromosomal location of PRODH, suggest a potential involvement of this gene in the 22q11-associated psychiatric and behavioural phenotypes. |
