| First Author | Bräuer AU | Year | 2003 |
| Journal | Nat Neurosci | Volume | 6 |
| Issue | 6 | Pages | 572-8 |
| PubMed ID | 12730698 | Mgi Jnum | J:85572 |
| Mgi Id | MGI:2675766 | Doi | 10.1038/nn1052 |
| Citation | Brauer AU, et al. (2003) A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci 6(6):572-8 |
| abstractText | Outgrowth of axons in the central nervous system is governed by specific molecular cues. Molecules detected so far act as ligands that bind to specific receptors. Here, we report a new membrane-associated lipid phosphate phosphatase that we have named plasticity-related gene 1 (PRG-1), which facilitates axonal outgrowth during development and regenerative sprouting. PRG-1 is specifically expressed in neurons and is located in the membranes of outgrowing axons. There, it acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. Thus, we propose a novel mechanism by which axons are able to control phospholipid-mediated signaling and overcome the growth-inhibiting, phospholipid-rich environment of the extracellular space. |
