| First Author | McMahon HT | Year | 1995 |
| Journal | Cell | Volume | 83 |
| Issue | 1 | Pages | 111-9 |
| PubMed ID | 7553862 | Mgi Jnum | J:29256 |
| Mgi Id | MGI:76787 | Doi | 10.1016/0092-8674(95)90239-2 |
| Citation | McMahon HT, et al. (1995) Complexins: cytosolic proteins that regulate SNAP receptor function. Cell 83(1):111-9 |
| abstractText | A family of proteins called complexins was discovered that compete with alpha-SNAP, but not synaptotagmin, for SNAP receptor binding. Complexins I and II are highly homologous hydrophilic proteins that are tightly conserved, with 100% identity among mouse, rat, and human complexin II. They are enriched in neurons where they colocalize with syntaxin and SNAP-25; in addition, complexin II is expressed ubiquitously at low levels. Complexins bind weakly to syntaxin alone and not at all to synaptobrevin and SNAP-25, but strongly to the SNAP receptor-core complex composed of these three molecules. They compete with alpha-SNAP for binding to the core complex but not with other interacting molecules, including synaptotagmin I, suggesting that the complexins regulate the sequential interactions of alpha-SNAP and synaptotagmins with the SNAP receptor during exocytosis. |
