| First Author | Matthews W | Year | 1991 |
| Journal | Cell | Volume | 65 |
| Issue | 7 | Pages | 1143-52 |
| PubMed ID | 1648448 | Mgi Jnum | J:11299 |
| Mgi Id | MGI:59738 | Doi | 10.1016/0092-8674(91)90010-v |
| Citation | Matthews W, et al. (1991) A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65(7):1143-52 |
| abstractText | To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny. |
