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Publication : Genomic organization of the interleukin-1 locus.

First Author  Taylor SL Year  2002
Journal  Genomics Volume  79
Issue  5 Pages  726-33
PubMed ID  11991723 Mgi Jnum  J:76507
Mgi Id  MGI:2179605 Doi  10.1006/geno.2002.6752
Citation  Taylor SL, et al. (2002) Genomic organization of the interleukin-1 locus. Genomics 79(5):726-33
abstractText  Recent additions have expanded the interleukin (IL)-1 gene family to 10 members. We have determined the order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of these genes. The order and orientation of the mouse genes have been mapped, and the mouse locus compared with the human locus. There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7. (c)2002 Elsevier Science (USA).
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