| First Author | Okumura F | Year | 2011 |
| Journal | Biochim Biophys Acta | Volume | 1813 |
| Issue | 10 | Pages | 1784-92 |
| PubMed ID | 21689689 | Mgi Jnum | J:177748 |
| Mgi Id | MGI:5295924 | Doi | 10.1016/j.bbamcr.2011.05.013 |
| Citation | Okumura F, et al. (2011) TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells. Biochim Biophys Acta 1813(10):1784-92 |
| abstractText | TRIM8 is a member of a protein family defined by the presence of a common domain structure composed of a tripartite motif including a RING-finger, one or two B-box domains and a coiled-coil motif. Here, we show that TRIM8 interacts with Hsp90beta, which interacts with STAT3 and selectively downregulates transcription of Nanog in embryonic stem cells. Knock-down of TRIM8 increased phosphorylated STAT3 in the nucleus and also enhanced transcription of Nanog. These findings suggest that TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells. |
