| First Author | Wu J | Year | 1999 |
| Journal | Science | Volume | 285 |
| Issue | 5428 | Pages | 730-2 |
| PubMed ID | 10426994 | Mgi Jnum | J:56494 |
| Mgi Id | MGI:1341449 | Doi | 10.1126/science.285.5428.730 |
| Citation | Wu J, et al. (1999) An activating immunoreceptor complex formed by NKG2D and DAP10 [see comments]. Science 285(5428):730-2 |
| abstractText | Many immune receptors are composed of separate ligand-binding and signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic domain, an Src homology 2 (SH2) domain-binding site was capable of recruiting the p85 subunit of the phosphatidylinositol 3-kinase (PI 3-kinase), providing for NKG2D-dependent signal transduction. Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors. |
