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Publication : BSPRY, a novel protein of the Ro-Ret family.

First Author  Schenker T Year  2000
Journal  Biochim Biophys Acta Volume  1493
Issue  1-2 Pages  255-8
PubMed ID  10978534 Mgi Jnum  J:75634
Mgi Id  MGI:2177159 Doi  10.1016/s0167-4781(00)00167-6
Citation  Schenker T, et al. (2000) BSPRY, a novel protein of the Ro-Ret family. Biochim Biophys Acta 1493(1-2):255-8
abstractText  Utilizing the yeast two-hybrid system we have identified a novel protein of the Ro-Ret family that was termed BSPRY. This protein is composed of a B-box, an alpha-helical coiled coil and a SPRY domain. BSPRY from human beings shares 80% sequence identity with the homologous protein from mice. The gene for BSPRY resides on human chromosome 9 and is specifically expressed in testis. It comprises six exons and five introns and possesses a GC rich promoter forming a typical CpG island. The function of BSPRY is not known, but several related proteins of the RBCC family have been implicated in cell transformation.
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