| First Author | Hsu YM | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 2 | Pages | 198-205 |
| PubMed ID | 17187069 | Mgi Jnum | J:117799 |
| Mgi Id | MGI:3697751 | Doi | 10.1038/ni1426 |
| Citation | Hsu YM, et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8(2):198-205 |
| abstractText | The caspase-recruitment domain-containing adaptor protein CARD9 regulates the innate signaling responses to fungal infection. Here we show that CARD9 is required for innate immune responses against intracellular pathogens. We generated Card9(-/-) mice and found that CARD9-deficient macrophages had defects in activation of the kinases p38 and Jnk but not of transcription factor NF-kappaB after bacterial and viral infection. CARD9-deficient mice failed to clear infection and showed altered cytokine production after challenge with Listeria monocytogenes. In wild-type cells, we found CARD9 inducibly associated with both the intracellular 'biosensor' Nod2 and the serine-threonine kinase RICK. Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens. |
