| First Author | Lin J | Year | 1997 |
| Journal | Endocrinology | Volume | 138 |
| Issue | 12 | Pages | 5535-40 |
| PubMed ID | 9389541 | Mgi Jnum | J:44463 |
| Mgi Id | MGI:1100246 | Doi | 10.1210/endo.138.12.5636 |
| Citation | Lin J, et al. (1997) Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta. Endocrinology 138(12):5535-40 |
| abstractText | Two novel members of the mouse PRL/GH family have been identified through a search of an expressed sequence tag database. The encoded proteins do not appear to be homologs of other known members of this hormone family. One of these proteins, designated PRL-like protein E (PLP-E), is predicted to be synthesized as a precursor of 265 amino acids, modified by N-linked glycosylation, and secreted as a mature glycoprotein of 236 residues. The second clone encodes a protein of 253 residues with consensus sites for N-linked glycosylation; the secreted form of the protein, designated PRL-like protein F (PLP-F), is predicted to be 223 amino acids in length. Both of these messenger RNAs are expressed specifically in the placenta, with peak levels of PLP-E on days 10-12 and of PLP-F on days 14-16. Expression of PLP-E is restricted to the trophoblast giant cells, whereas PLP-F is synthesized only in the spongiotrophoblasts. The genes for both of these proteins map to a 700-kilobase region of mouse chromosome 13 that includes other members of the PRL/GH family. |
