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Publication : Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1.

First Author  Heesen M Year  1998
Journal  Immunogenetics Volume  47
Issue  5 Pages  364-70
PubMed ID  9510554 Mgi Jnum  J:47562
Mgi Id  MGI:1203775 Citation  Heesen M, et al. (1998) Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Immunogenetics 47(5):364-70
abstractText  Degenerate RT-PCR was used to identify a new seven-transmembrane-spanning receptor expressed in astrocytes. A receptor, termed RDC1, displaying the characteristic structural features of a chemokine receptor was cloned. The predicted 362-amino-acid sequence displayed 92% and 91% similarity to the human and dog orphan receptor RDC1, respectively. In addition, RDC1 shares 43% amino acid similarity to rabbit and mouse CXCR2. Transcripts of RDC1 were found in astrocytes, heart, kidney, the mesangial tumor line MES-13, spleen, and neutrophils by means of northern blot. Using linkage analysis of interspecies backcross mice, we localized to chromosome 1 the genes for mouse CXCR2, CXCR4, and RDC1. Mouse RDC1 is linked to and lies between the genes for the mouse CXC chemokine receptors CXCR2 and CXCR4. The combined data of chromosomal location and sequence similarity suggest that RDC1 is an orphan CXC chemokine receptor.
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