| First Author | Foletta VC | Year | 1994 |
| Journal | Oncogene | Volume | 9 |
| Issue | 11 | Pages | 3305-11 |
| PubMed ID | 7936655 | Mgi Jnum | J:21147 |
| Mgi Id | MGI:69186 | Citation | Foletta VC, et al. (1994) Cloning and characterisation of the mouse fra-2 gene. Oncogene 9(11):3305-11 |
| abstractText | Transcription factor AP-1 is comprised of multiple protein complexes that include members of a family of genes related to the proto-oncogene c-fos. In this report, we have extended the analysis of one member of this family, fos-related antigen-2 (fra-2), by isolating and characterising genomic and cDNA clones encoding the mouse fra-2 homolog. The overall gene structure (number and positions of introns) was similar to that of both the chicken fra-2 gene and other members of the fos family, and the relative positions of putative enhancers in the 5' regulatory region were well conserved between the mouse and chicken fra-2 genes. High levels of fra-2 mRNA were detected in ovary, stomach, small and large intestine, brain, lung and heart. The mouse Fra-2 protein showed 94% and 87.5% conservation with human and chicken Fra-2, respectively, and mouse Fra-2, like the chicken homolog, induced transformation of chicken embryo fibroblasts. The characterisation of the mouse fra-2 gene provides a basis for analysis of Fra-2 function in the whole animal. |
