| First Author | Jiménez-Lara AM | Year | 2002 |
| Journal | FEBS Lett | Volume | 526 |
| Issue | 1-3 | Pages | 142-6 |
| PubMed ID | 12208521 | Mgi Jnum | J:82166 |
| Mgi Id | MGI:2651387 | Doi | 10.1016/s0014-5793(02)03154-x |
| Citation | Jimenez-Lara AM, et al. (2002) PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2. FEBS Lett 526(1-3):142-6 |
| abstractText | PIAS3, a member of the protein inhibitor of activated STAT family, was found to interact in vivo and in vitro with TIF2, a previously described coactivator for nuclear receptors. The interaction is mediated by two distinct non-contiguous regions of TIF2. We found that TIF2-PIAS3 interaction occurs through a unique domain of PIAS3, very rich in acidic residues and conserved throughout the PIAS family. PIAS3 modulates the ability of TIF2 to mediate ligand-enhanced transcription activation positively or negatively, for different steroid receptors. Taken together, our results indicate a potential role of PIAS3 as transcriptional modulator of TIF2-mediated signalling. |
