| First Author | Malarkannan S | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 3 | Pages | 333-44 |
| PubMed ID | 11021531 | Mgi Jnum | J:64705 |
| Mgi Id | MGI:1889894 | Doi | 10.1016/s1074-7613(00)00033-9 |
| Citation | Malarkannan S, et al. (2000) Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens. Immunity 13(3):333-44 |
| abstractText | Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells. |
