| First Author | Serafini T | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 6 | Pages | 1001-14 |
| PubMed ID | 8978605 | Mgi Jnum | J:37125 |
| Mgi Id | MGI:84553 | Doi | 10.1016/s0092-8674(00)81795-x |
| Citation | Serafini T, et al. (1996) Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87(6):1001-14 |
| abstractText | During nervous system development, spinal commissural axons project toward floor plate cells and trochlear motor axons extend away from these cells. Netrin-1, a diffusible protein made by floor plate cells, can attract spinal commissural axons and repel trochlear axons in vitro, but its role in vivo is unknown. Netrin-1 deficient mice exhibit defects in spinal commissural axon projections that are consistent with netrin-1 guiding these axons. Defects in several forebrain commissures are also observed, suggesting additional guidance roles for netrin- 1. Trochlear axon projections are largely normal, predicting the existence of additional cues for these axons, and evidence is provided for a distinct trochlear axon chemorepellent produced by floor plate cells. These results establish netrin-1 as a guidance cue that likely collaborates with other diffusible cues to guide axons in vivo. |
