| First Author | Steeg PS | Year | 1988 |
| Journal | J Natl Cancer Inst | Volume | 80 |
| Issue | 3 | Pages | 200-4 |
| PubMed ID | 3346912 | Mgi Jnum | J:15840 |
| Mgi Id | MGI:63951 | Doi | 10.1093/jnci/80.3.200 |
| Citation | Steeg PS, et al. (1988) Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 80(3):200-4 |
| abstractText | We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identified, and (2) N-nitroso-N-methylurea-induced rat mammary carcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsic aggressiveness. The predicted carboxy-terminal protein sequence encoded by the pNM23 cDNA clone is novel compared with Genebank animal, bacterial, and viral sequences. |
