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Publication : Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene.

First Author  Suzuki K Year  1996
Journal  Genomics Volume  36
Issue  2 Pages  263-70
PubMed ID  8812452 Mgi Jnum  J:35445
Mgi Id  MGI:82894 Doi  10.1006/geno.1996.0461
Citation  Suzuki K, et al. (1996) Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene. Genomics 36(2):263-70
abstractText  Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEE-1) and is implicated in neural development. Isolation and characterization of the cosmid clones encoding the mouse ETF gene (Etdf) revealed that Etdf spans approximately 17.9 kb and consists of 12 exons. The exon-intron structure of Etdf closely resembles that of the Drosophila scalloped gene, indicating that these genes may have evolved from a common ancestor. The multiple transcription initiation sites revealed by S1 protection and primer extension analyses are consistent with the absence of the canonical TATA and CAAT boxes in the 5'-flanking region, which contains many potential regulatory sequences, such as the E-box, N-box, Spl element, GATA-1 element, TAATGARAT element, and B2 short interspersed element (SINE) as well as several direct and inverted repeat sequences. The Etdf locus was assigned to the proximal region of mouse chromosome 7 using fluorescence in situ hybridization and linkage mapping analyses. These results provide the molecular basis for studying the regulation, in vivo function, and evolution of Etdf. (C) 1996 Academic Press, Inc.
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