| First Author | Tao W | Year | 2001 |
| Journal | Genes Dev | Volume | 15 |
| Issue | 14 | Pages | 1796-807 |
| PubMed ID | 11459829 | Mgi Jnum | J:70543 |
| Mgi Id | MGI:2137761 | Doi | 10.1101/gad.894301 |
| Citation | Tao W, et al. (2001) Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15(14):1796-807 |
| abstractText | We report the isolation and cloning of the Wrch-1 (Wnt-1 responsive Cdc42 homolog) cDNA. Wrch-1 is a novel gene whose mRNA level increases in response to Wnt-1 signaling in Wnt-1 transformed cells, Wnt-1 transgene induced mouse mammary tumors, and Wnt-1 retrovirus infected cells. Wrch-1 encodes a homolog of the Rho family of GTPases. It shares 57% amino acid sequence identity with Cdc42, but possesses a unique N-terminal domain that contains several putative PXXP SH3-binding motifs. Like Cdc42, Wrch-1 can activate PAK-1 and JNK-1, and induce filopodium formation and stress fiber dissolution. Active Wrch-1 stimulates quiescent cells to reenter the cell cycle. Moreover, overexpression of Wrch-1 phenocopies Wnt-1 in morphological transformation of mouse mammary epithelial cells. Taken together, Wrch-1 could mediate the effects of Wnt-1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. |
