| First Author | Numoto M | Year | 1993 |
| Journal | Nucleic Acids Res | Volume | 21 |
| Issue | 16 | Pages | 3767-75 |
| PubMed ID | 8367294 | Mgi Jnum | J:25666 |
| Mgi Id | MGI:73378 | Doi | 10.1093/nar/21.16.3767 |
| Citation | Numoto M, et al. (1993) Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins. Nucleic Acids Res 21(16):3767-75 |
| abstractText | We have cloned a cDNA encoding a new murine C2H2 zinc finger protein, ZF5. The 51.3 kD protein contains five GL1-Kruppel type zinc fingers at the C-terminus. At its N-terminus, ZF5 has a 41 amino acid region which was found to be homologous to the N-termini of several other zinc finger proteins. This region defines a new motif within zinc finger proteins which we have named the Zinc finger N-terminal (ZiN) domain. ZF5 binds to two sites in the c-myc promoter and to the -50 bp site of the herpes simplex thymidine kinase promoter. ZF5 is a transcriptional repressor and its repression domain is located N-terminal to the zinc finger domains. A single 4 kb ZF5 mRNA is expressed widely. |
