| First Author | Bulfone A | Year | 1995 |
| Journal | Neuron | Volume | 15 |
| Issue | 1 | Pages | 63-78 |
| PubMed ID | 7619531 | Mgi Jnum | J:27413 |
| Mgi Id | MGI:74856 | Doi | 10.1016/0896-6273(95)90065-9 |
| Citation | Bulfone A, et al. (1995) T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron 15(1):63-78 |
| abstractText | The mechanisms that regulate regional specification and evolution of the cerebral cortex are obscure. To this end, we have identified and characterized a novel murine and human gene encoding a putative transcription factor related to the Brachyury (T) gene that is expressed only in postmitotic cells. T-brain-1 (Tbr-1) mRNA is largely restricted to the cerebral cortex, where during embryogenesis it distinguishes domains that we propose may give rise to paleocortex, limbic cortex, and neocortex. Tbr-1 and Id-2 expression in the neocortex have discontinuities that define molecularly distinct neocortical areas. Tbr-1 expression is analyzed in the context of the prosomeric model. Topological maps are proposed for the organization of the dorsal telencephalon. |
