| First Author | Sasaki Y | Year | 2016 |
| Journal | Elife | Volume | 5 |
| PubMed ID | 27735788 | Mgi Jnum | J:269726 |
| Mgi Id | MGI:6206974 | Doi | 10.7554/eLife.19749 |
| Citation | Sasaki Y, et al. (2016) NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion. Elife 5:e19749 |
| abstractText | Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure. Using steady-state and flux analysis of NAD(+) metabolites in healthy and injured mouse dorsal root ganglion axons, we find that rather than altering NAD(+) synthesis, NMNAT1 instead blocks the injury-induced, SARM1-dependent NAD(+) consumption that is central to axon degeneration. |
