| First Author | Lacana E | Year | 1999 |
| Journal | Nat Med | Volume | 5 |
| Issue | 5 | Pages | 542-7 |
| PubMed ID | 10229231 | Mgi Jnum | J:54444 |
| Mgi Id | MGI:1335914 | Doi | 10.1038/8420 |
| Citation | Lacana' E, et al. (1999) Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4. Nat Med 5(5):542-7 |
| abstractText | Programmed cell death is a process required for the normal development of an organism. One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas/Fas ligand (FasL) interaction. During studies of apoptosis induced by T cell-receptor engagement, we identified ALG-4F, a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death. Overexpression of full-length ALG-4 induced transcription of FasL and, consequently, apoptosis. These results indicate that ALG-4 is necessary and sufficient for FasL expression. Fas/FasL interaction initiates cell death in many other systems, and its dysregulation is a mechanism by which several pathologic conditions arise. Understanding the molecular mechanisms of FasL regulation could be very useful in elucidating how these diseases develop and in identifying potential therapeutic targets. |
