| First Author | Ikeda K | Year | 1992 |
| Journal | FEBS Lett | Volume | 313 |
| Issue | 1 | Pages | 34-8 |
| PubMed ID | 1385220 | Mgi Jnum | J:3203 |
| Mgi Id | MGI:51718 | Doi | 10.1016/0014-5793(92)81178-o |
| Citation | Ikeda K, et al. (1992) Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett 313(1):34-8 |
| abstractText | The primary structure of a novel subunit of the mouse NMDA (N-methyl-D-aspartate) receptor channel, designated epsilon 4, has been revealed by cloning and sequencing the cDNA. The epsilon 4 subunit shares high amino acid sequence identity with the epsilon 1, epsilon 2 and epsilon 3 subunits of the mouse NMDA receptor channel, thus constituting the epsilon subfamily of the glutamate receptor channel. Expression from cloned cDNAs of the epsilon 4 subunit together with the zeta 1 subunit in Xenopus oocytes yields functional NMDA receptor channels. The epsilon 4/zeta 1 heteromeric channel exhibits high apparent affinities for agonists and low sensitivities to competitive antagonists. The epsilon 4 subunit is thus distinct in functional properties from the epsilon 1, epsilon 2 and epsilon 3 subunits, and contributes further diversity of the NMDA receptor channel. |
