| First Author | Lee DS | Year | 2000 |
| Journal | J Biol Chem | Volume | 275 |
| Issue | 30 | Pages | 23134-8 |
| PubMed ID | 10833507 | Mgi Jnum | J:63596 |
| Mgi Id | MGI:1861275 | Doi | 10.1074/jbc.C000302200 |
| Citation | Lee DS, et al. (2000) Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem 275(30):23134-8 |
| abstractText | We isolated a cDNA encoding a novel protein, XB51, that interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L). The protein XB51 inhibited the association of X11L with amyloid precursor protein through a non-competitive mechanism and abolished the suppression of beta-amyloid production by X11L. The majority of XB51 is localized around the nucleus and recovered in 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid (CHAPS) buffer-insoluble fraction when XB51 is expressed in cells. Association of XB51 with X11L changed the intracellular distribution of XB51 and resulted in redistribution of XB51 into the CHAPS buffer-soluble fraction. These observations suggest that XB51, together with X11L, plays an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. |
