| First Author | Schimenti J | Year | 1988 |
| Journal | Cell | Volume | 55 |
| Issue | 1 | Pages | 71-8 |
| PubMed ID | 3167978 | Mgi Jnum | J:9375 |
| Mgi Id | MGI:57836 | Doi | 10.1016/0092-8674(88)90010-4 |
| Citation | Schimenti J, et al. (1988) A candidate gene family for the mouse t complex responder (Tcr) locus responsible for haploid effects on sperm function. Cell 55(1):71-8 |
| abstractText | The mouse t complex responder (Tcr) locus plays a central haploid-specific role in the transmission ratio distortion phenotype expressed during germ cell differentiation in t-carrying males. The accumulated data map Tcr to a region of less than 500 kb. Over 400 kb of this region has been cloned and consists entirely of sequences associated with a clustered family of large cross-hybridizing elements of 30 kb to 70 kb in size. We have characterized a gene family within this region that is expressed uniquely in male germ cells with a complex pattern of RNA processing. Antibodies produced against a product of the putative open reading frame recognize a testes-specific polypeptide. Genetic data support the hypothesis that this polypeptide(s) functions to effect the Tcr phenotype. |
