| First Author | Kawasaki-Nishi S | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 364 |
| Issue | 4 | Pages | 1032-6 |
| PubMed ID | 17971301 | Mgi Jnum | J:128432 |
| Mgi Id | MGI:3767110 | Doi | 10.1016/j.bbrc.2007.10.118 |
| Citation | Kawasaki-Nishi S, et al. (2007) Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit. Biochem Biophys Res Commun 364(4):1032-6 |
| abstractText | We have identified splicing variants of the mouse a4 subunit which have the same open reading frame but have a different 5'-noncoding sequence. Further determination of the 5'-upstream region of the a4 gene in mouse indicated the presence of two first exons (exon 1a and exon 1b) which include the 5'-noncoding sequence of each variant. The mRNAs of both splicing variants (a4-I and a4-II) show a similar expression pattern in mouse kidney by in situ hybridization. However, tissue and developmental expression patterns of the variants are different. In addition to strong expression in kidney, a4-I expression was detected in heart, lung, skeletal muscle, and testis, whereas a4-II is expressed in lung, liver, and testis. During development, a4-I was expressed beginning with the early embryonic stage, but a4-II mRNA was detected from day 17. These results suggest that each a4 variant has both a tissue and developmental stage specific function. |
