| Type | subunit | Description | Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG2, CATSPERD, CATSPERE, CATSPERZ, SLCO6C1, TMEM249, TMEM262 and EFCAB9 (PubMed:34225353, PubMed:21224844, PubMed:17478420, PubMed:19516020, PubMed:17227845). HSPA1 may be an additional auxiliary complex member (PubMed:17478420, PubMed:19516020). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (PubMed:34225353). The auxiliary CATSPERB, CATSPERG2, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 AND CATSPER2 respectively (PubMed:34225353). SLCO6C1 interacts with CATSPERE, and TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (PubMed:34225353). Interacts with Ca(v)3.3/CACNA1I, leading to suppression of T-type calcium channel activity (By similarity). |
